Bioprocess Engineering Principles – Pauline M. Doran – 1st Edition


The emergence and refinement of techniques in molecular biology has changed our perceptions of medicine, agriculture, and environmental management. Scientific breakthroughs in expression, protein engineering, and cell fusion are being translated by a strengthening industry into revolutionary new products and services.

Many a has been enticed by the promise of biotechnology and the excitement of being near the cutting edge of scientific advancement. However, graduates trained in molecular biology and cell manipulation soon realise that these techniques are only part of the picture. Reaping the full benefits of biotechnology requires manufacturing capability involving the large-scale of material.

Increasingly, biotechnologists are being employed by companies to work in cooperation with chemical to achieve pragmatic commercial goals. For many years, aspects of biochemistry and molecular genetics have been included in chemical engineering curricula, yet there has been little attempt until recently to teach aspects of engineering applicable to process design to biotechnologists.

This textbook is the first to present the principles of bioprocess engineering in a way that is accessible to biological scientists. Other texts on bioprocess engineering currently available assume that the reader already has engineering training. On the other hand, chemical engineering textbooks do not consider examples from bioprocessing, and are written almost exclusively with the petroleum and chemical industries in mind.

This publication explains process analysis from an engineering point of view, but refers exclusively to the treatment of biological systems. Over 170 and worked examples encompass a wide range of applications, recombinant plant and animal cell cultures, immobilised catalysts, as well as traditional fermentation systems.

Table of Content

    Part I. Introduction
  1. Bioprocess Development: An Interdisciplinary Challenge

  2. Introduction to Engineering Calculations

  3. Presentation and Analysis of Data

  4. Part II. Material and Energy Balances
  5. Material Balances

  6. Energy Balances

  7. Unsteady-State Material and Energy Balances

  8. Part III. Physical Processes
  9. Fluid Flow and Mixing

  10. Heat Transfer

  11. Mass Transfer

  12. Unit Operations

  13. Reactions and Reactors
  14. Homogenous Reactions

  15. Heterogenous Reactions

  16. Reaction Engineering

Conversion Factors
Physical and Chemical Property Data
Steam Tables
Mathematical Rules

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